Health and Medicine (Audio)

More than 7 million Americans are living with Alzheimer's, according to the Alzheimer's Association. UC Davis researcher Alyssa Weakley is working on I-Care, a new technology that's helping Alzheimer's patients live longer in their own homes.

At UC Davis, our researchers are working to better understand the causes of dementia, including Alzheimer’s, its most common form, while advancing understanding and improving care for those affected. Through innovative studies, we’re paving the way for new treatments and strategies to slow, prevent and ultimately transform how we approach these complex neurological conditions. Series: "UC Davis News" [Health and Medicine] [Show ID: 41737]

Social isolation may influence how the body recovers from pelvic floor injury after childbirth. Lindsay Burnett, M.D., Ph.D., assistant professor and physician-scientist at UC San Diego, studies factors during pregnancy and postpartum that may affect pelvic floor muscle recovery, including medications, diet, exercise and social interaction. Her research grew from clinical observations connecting patients’ perceptions of traumatic births with physical outcomes such as fecal incontinence. In a preclinical model, social support was associated with improved pelvic floor muscle regeneration and distinct metabolic changes. Burnett is investigating metabolites involved in wound healing and skeletal muscle regeneration, along with possible connections between social interaction, the gut microbiome and systemic metabolism. The research offers a biological perspective on why emotional and social support may matter during postpartum recovery.
Series: "Motherhood Channel" [Health and Medicine] [Show ID: 41640]

Mechanical forces may help the body coordinate pregnancy and labor. Yunxiao Zhang, Ph.D., of Scripps Research Institute, examines how PIEZO1 and PIEZO2, proteins that open in response to stretch, contribute to uterine contractions and the timing of birth. Zhang finds PIEZO1 in uterine smooth muscle and PIEZO2 in sensory nerve fibers around the cervix. In mouse models, removing both channels weakens labor contractions, delays the start of delivery and increases the time between pups. The findings suggest that PIEZO1 helps prepare uterine muscle for stronger contractions, while PIEZO2 helps sensory nerves detect cervical stretch. Zhang also discusses how fats in cell membranes may change PIEZO1 sensitivity and why uterine cells and sensory nerves have connected roles. This research offers a new way to study how physical forces help regulate labor.
Series: "Motherhood Channel" [Health and Medicine] [Show ID: 41642]

David Brockman suffered a traumatic accident in 2019 that led to the amputation of his hand from the wrist down. Following his surgery at the UC Davis Medical Center, he was connected with engineering professor Jonathon Schofield, who collaborates with Ph.D. students on prosthetic technology.

Through federally funded research projects, these students were able to design and provide Brockman with a custom myoelectric hand —a prosthetic he can control electronically. He emphasizes that without federal funding, schools and researchers wouldn’t have the resources to develop these innovations.

"My hand prosthetic would not have been available to me without funding.Without that money, these schools can’t do that and give people a chance to see what is possible.” — David Brockman Series: "UC Davis News" [Public Affairs] [Health and Medicine] [Show ID: 41733]

Chancellor May stops by the UC Davis Neuroprosthetics Lab to meet the researchers behind brain-computer interface technology. The technology helped a man with ALS communicate again with his family and used AI to mimic the sound of his own voice. Watch as Chancellor May tries out the technology himself in a lab simulation. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 41741]