Dwarkesh Podcast

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Fully autonomous robots are much closer than you think – Sergey Levine
Sergey Levine, one of the world’s top robotics researchers and co-founder of Physical Intelligence, thinks we’re on the cusp of a “self-improvement flywheel” for general-purpose robots. His median estimate for when robots will be able to run households entirely autonomously? 2030.If Sergey’s right, the world 5 years from now will be an insanely different place than it is today. This conversation focuses on understanding how we get there: we dive into foundation models for robotics, and how we scale both the data and the hardware necessary to enable a full-blown robotics explosion.Watch on YouTube; listen on Apple Podcasts or Spotify.Sponsors* Labelbox provides high-quality robotics training data across a wide range of platforms and tasks. From simple object handling to complex workflows, Labelbox can get you the data you need to scale your robotics research. Learn more at labelbox.com/dwarkesh* Hudson River Trading uses cutting-edge ML and terabytes of historical market data to predict future prices. I got to try my hand at this fascinating prediction problem with help from one of HRT’s senior researchers. If you’re curious about how it all works, go to hudson-trading.com/dwarkesh* Gemini 2.5 Flash Image (aka nano banana) isn’t just for generating fun images — it’s also a powerful tool for restoring old photos and digitizing documents. Test it yourself in the Gemini App or in Google’s AI Studio: ai.studio/bananaTo sponsor a future episode, visit dwarkesh.com/advertise.Timestamps(00:00:00) – Timeline to widely deployed autonomous robots(00:17:25) – Why robotics will scale faster than self-driving cars(00:27:28) – How vision-language-action models work(00:45:37) – Changes needed for brainlike efficiency in robots(00:57:59) – Learning from simulation(01:09:18) – How much will robots speed up AI buildouts?(01:18:01) – If hardware’s the bottleneck, does China win by default? Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
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1:28:28
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1:28:28
How Hitler almost starved Britain – Sarah Paine
In this lecture, military historian Sarah Paine explains how Britain used sea control, peripheral campaigns, and alliances to defeat Nazi Germany during WWII. She then applies this framework to today, arguing that Russia and China are similarly constrained by their geography, making them vulnerable in any conflict with maritime powers (like the U.S. and its allies).Watch on YouTube; listen on Apple Podcasts or Spotify.Sponsors* Labelbox partners with researchers to scope, generate, and deliver the exact data frontier models need, no matter the domain. Whether that’s multi-turn audio, SOTA robotics data, advanced STEM problem sets, or even novel RL environments, Labelbox delivers high-quality data, fast. Learn more at labelbox.com/dwarkesh* Warp is the best interface I’ve found for coding with agents. It makes building custom tools easy: Warp’s UI helps you understand agent behavior and its in-line text editor is great for making tweaks. You can try Warp for free, or, for a limited time, use code DWARKESH to get Warp’s Pro Plan for only $5. Go to warp.dev/dwarkeshTo sponsor a future episode, visit dwarkesh.com/advertise.Timestamps00:00:00 – How WW1 shaped WW200:15:10 – Hitler and Churchill’s battle to command the Atlantic00:30:10 – Peripheral theaters leading up to Normandy00:37:13 – The Eastern front00:48:04 – Russia’s & China’s geographic prisons01:00:28 – Hitler’s blunders & America’s industrial might01:15:03 – Bismarck’s limited wars vs Hitler’s total war Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
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1:35:17
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1:35:17
Evolution designed us to die fast; we can change that — Jacob Kimmel
Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.Watch on YouTube; listen on Apple Podcasts or Spotify.SPONSORS* Hudson River Trading uses deep learning to tackle one of the world's most complex systems: global capital allocation. They have a massive in-house GPU cluster, and they’re constantly adding new racks of B200s to ensure their researchers are never constrained by compute. Explore opportunities at hudsonrivertrading.com/dwarkesh\* Google’s Gemini CLI turns ideas into working applications FAST, no coding required. It built a complete podcast post-production tool in 10 minutes, including fully functional backend logic, and the entire build used less than 10% of Gemini’s session context. Check it out on Github now!* To sponsor a future episode, visit dwarkesh.com/advertise.TIMESTAMPS(00:00:00) – Three reasons evolution didn’t optimize for longevity(00:12:07) – Why didn't humans evolve their own antibiotics?(00:25:26) – De-aging cells via epigenetic reprogramming(00:44:43) – Viral vectors and other delivery mechanisms(01:06:22) – Synthetic transcription factors(01:09:31) – Can virtual cells break Eroom’s Law?(01:31:32) – Economic models for pharma Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
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1:44:40
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1:44:40
China is killing the US on energy. Does that mean they’ll win AGI? — Casey Handmer
How will we feed the 100s of GWs of extra energy demand that AI will create over the coming decade? On this episode, Casey Handmer (Caltech PhD, former NASA JPL, founder & CEO of Terraform Industries) walks me through how we can pull it off, and why he thinks a major part of this energy singularity will be powered by solar. His views are contrarian, but he came armed to defend them.Watch on YouTube; listen on Apple Podcasts or Spotify.SPONSORS- Lighthouse helps frontier technology companies like Cursor and Physical Intelligence navigate the U.S. immigration system and hire top talent from around the world. Lighthouse handles everything for you, maximizing the probability of visa approval while minimizing the work you have to do. Learn more at lighthousehq.com/employers- To sponsor a future episode, visit dwarkesh.com/advertise.TIMESTAMPS(00:00:00) – Why doesn’t China win by default?(00:08:28) – Why hyperscalers choose natural gas over solar(00:18:01) – Solar's astonishing learning rates(00:27:02) – How to build 50,000 acre solar-powered data centers(00:40:24) – Environmental regulations blocking clean energy(00:44:04) – Batteries replacing the grid(00:49:14) – GDP is broken, AGI's true value must be measured in total energy use(00:58:45) – Silicon wafers in space with one mind each Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
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1:08:22
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1:08:22
Artificial meat is harder than artificial intelligence — Lewis Bollard
A deep dive with Lewis Bollard, who leads Open Philanthropy’s strategy for Farmed Animal Welfare, on the surprising economics of the meat industry.Why is factory farming so efficient? How can we make the lives of the 23+ billion animals living on factory farms more bearable? How far off are the moonshots (e.g., brainless chickens, cultivated meats, etc.) to end this mass suffering? And why does the meat industry have such a surprising amount of political influence?For decades, innovation in the meat industry has actually made the conditions for animals worse. Can the next few decades of tech reverse this pattern?Watch on YouTube; listen on Apple Podcasts or Spotify.Donation match fundraiserThe welfare of animals on factory farms is so systemically neglected that just $1 can help avert 10 years of animal suffering.After learning more about the outsized opportunities to help, I decided to give $250,000 as a donation match to farmkind.giving/dwarkesh. FarmKind directs your contributions to the most effective charities in this area.Please consider contributing, even if it’s a small amount. Together, we can double each other's impact and give a total of $500,000.Bluntly, there are some listeners who are in a position to give much more. Given how neglected this topic is, one such person could singlehandedly change the game for 10s of billions of animals. If you’re considering donating $50k or more, please reach out directly to Lewis and his team by emailing [email protected](00:00:00) – The astonishing efficiency of factory farming(00:07:18) – It was a mistake making this about diet(00:09:54) – Tech that’s sparing 100s of millions of animals/year(00:16:16) – Brainless chickens and higher welfare breeds(00:28:21) – $1 can prevent 10 years of animal suffering(00:37:26) – Situation in China and the developing world(00:41:41) – How the meat lobby got a lock on Congress(00:53:23) – Business structure of the meat industry(00:57:42) – Corporate campaigns are underrated Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
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1:08:05
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1:08:05