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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • 10-Minute Weekly Update : 1335
    Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts. This episode covers: - Rapamycin’s Reality Check: A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs. Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025 - Senolytics Get Precise: New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all. Source: Aging-US research stream – September 23, 2025 - AI Healthcare: Promise and Pause: The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain. Source: Crescendo.ai – September 23, 2025 - Medical Policy Meets Machine Logic: A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access. Source: KFF Health News policy rundown – September 25, 2025 - Longevity Headlines You Can Use: Forest bathing wins renewed praise for helping with blood pressure and stress. Northwestern’s SuperAger project links strong social ties to resilient brain health. Human trials now test an antibody therapy to regrow lost teeth. Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025 Action steps for the week: Try fasting windows and smart protein clustering for mTOR modulation. Let AI help summarize your health data—but get decisions confirmed by your clinician. If you or your family touch Medicare, keep thorough documentation and demand human review. Soak in green spaces, reconnect socially, and watch for cutting-edge therapies. All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Rapamycin Hype Check 1:07 — Senolytics Leveled Up 2:41 — AI in Healthcare 3:11 — AI Between You and Your Doctor 5:50 — Three Longevity Angles 7:59 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Why you absolutely MUST take algae daily to protect your longevity : 1334
    Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research. Watch the condensed video highlight version of this episode (and much more!) on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits, recent PhD graduate, and one of the world’s top experts on algae and functional medicine. Entering her 70th year without medications, with the cognition to finish a doctorate, and the health markers of someone decades younger, Catharine is living proof of how mitochondria and nutrition shape aging, brain optimization, and resilience. Together they break down why mitochondria fail after age 30, how algae works as a master supplement to restore superoxide dismutase (SOD) and glutathione, and what happens when you give your cells the nutrients they’re wired to need. They uncover how mitochondria connect to energy, inflammation, metabolism, and cellular resilience. This is a masterclass in hacking energy and longevity, built for people who want to upgrade every system of the body and mind. You’ll learn: • Why mitochondria decline after age 30 and how to stop it • The role of superoxide dismutase (SOD) and glutathione in preventing cellular “rust” • How spirulina and chlorella outperform most supplements for detox and energy • The connection between mitochondria and brain optimization • Why men’s higher iron levels accelerate aging and how algae helps balance it • The real link between metabolism, inflammation, and longevity • How to build a mitochondria-first biohacking stack that actually works This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Catharine Arnston, mitochondria, biohacking, algae supplements, spirulina, chlorella, superoxide dismutase, SOD, glutathione, metabolism, longevity, human performance, brain optimization, functional medicine, supplements, neuroplasticity, nootropics, ketosis, fasting, cold therapy, sleep optimization, carnivore, Danger Coffee, Smarter Not Harder, Dave Asprey, Human Upgrade podcast **CTA: Go to www.energybits.com and use code ‘BEYOND’ for a 20% discount** Thank you to our sponsors! HeartMath | Go to https://www.heartmath.com/dave to save 15% off. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. STEMREGEN | Go to https://stemregen.co/dave25 and use code DAVE25 for 25% off your order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:18 — Intro 3:03 — Longevity & Algae 8:48 — Mitochondria & ATP 13:08 — Free Radicals & SOD 13:18 — Aging After 30 17:18 — Men vs Women in Aging 24:18 — Mitochondrial Breakdown 30:03 — Algae for Mitochondria 37:18 — SOD, Glutathione & Manganese 45:18 — Algae Dosing Tips 51:18 — Processing & Quality 58:18 — Carnivore vs Plants 1:00:48 — Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Steven Pinker: Outsmarting an Irrational World : 1333
    Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you. Watch the condensed video highlight version of this episode (and much more!) on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Steven Pinker, a world-renowned cognitive psychologist, Harvard professor, and bestselling author whose research reshaped how we understand language, bias, social norms, and rationality. Pinker’s decades of scholarship make him a trusted guide to the mechanics of the mind and the behaviors that either elevate or derail human performance and longevity. Together they break down how the brain actually reasons, why smart people still fall for tribal thinking, what current AI gets wrong about human intelligence, and how “common knowledge” quietly governs cooperation, law, and civility. This is a masterclass in brain optimization through better thinking, built for people who care about biohacking, hacking mental models, neuroplasticity, and high-performance decision-making. You’ll learn: • How to recognize and counter the “my-side bias,” even if you’re highly intelligent • Why common knowledge creates and sustains social norms and coordination • The art of indirect speech and tact, and how to calibrate your words to reduce social risk • Simple upgrades that make video calls feel closer to real eye contact and why that boosts trust • What today’s AI gets wrong about minds and why models hallucinate • Rational habits that work in the real world: steelmanning, probabilistic thinking, adversarial collaboration, and making bets as a tax on bad arguments • Why liberal democracy fits human nature better than autocracy and how norms erode or hold • How to rebuild face-to-face social skills in a screen-first culture to improve resilience and performance This is essential listening for fans of biohacking, brain optimization, human performance, neuroplasticity, and longevity who want clear, usable frameworks to think better and live better with Dave Asprey. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Steven Pinker, cognitive psychology, rational thinking, my-side bias, human nature, common knowledge, cognitive bias, AI and human intelligence, democracy and human behavior, social norms psychology, decision-making hacks, brain optimization, biohacking the mind, mental performance, neuroplasticity, rationality movement, bias and longevity, functional intelligence, Human Upgrade podcast, Dave Asprey, thinking traps, steelmanning, epistemic humility, outrage economy, psychology of power, critical thinking upgrade, hacking human performance Thank you to our sponsors! KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. **Order Steven’s new book WHEN EVERYONE KNOWS THAT EVERYONE KNOWS...: COMMON KNOWLEDGE AND THE MYSTERIES OF MONEY, POWER, AND EVERYDAY LIFE: HTTPS://TINYURL.COM/V685EVZR Resources: • Steven’s Website: https://stevenpinker.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 0:59 — Introduction 1:58 — Human Nature 3:30 — Cognitive Psychology 5:46 — Academia Path 7:32 — Canada vs. U.S. 8:42 — College Value 12:08 — Curiosity 15:25 — Government & Humans 19:56 — AI & Cognition 24:45 — Fairness & Justice 32:56 — Social Norms 47:12 — Communication Skills 55:32 — Virtual Society 57:20 — Personal Biases See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • How To Clear Brain Fog (Simple Methods) : 1332
    If you feel like your brain's stuck in first gear, losing focus, forgetting simple things, feeling mentally sluggish—you’re not alone. I lived with brain fog for 15 years while building companies in Silicon Valley, and no productivity hack or double espresso fixed it. In this episode, I’ll show you how to clear brain fog at the cellular level by restoring mitochondrial energy, ditching brain-damaging foods, optimizing sleep, and upgrading your nutrition. These are the exact science-backed steps that got me back to feeling sharp, focused, and fully me. Let’s turn your brain back on.Chapters:0:00 – Introduction0:49 – The Root Cause of Brain Fog1:26 – What Most People Get Wrong2:20 – How to Fix Your Mitochondria2:57 – Food: Fuel or Poison4:48 – The 4 Brain Poisons Killing Your Focus5:20 – Exercise for Brain Energy (Not Burnout)7:55 – Brain Fog Supplements That WorkBrain fog supplement: https://shopsuppgradelabs.com/products/brain-101, use code DAVE15 Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Lisa Bilyeu: How to hack confidence : 1331
    Confidence is biology you can hack. In this episode, you’ll see how confidence builds inside your brain, rewires through neuroplasticity, and connects directly to mitochondria, metabolism, and human performance. You’ll get tools that reprogram fear, regulate your nervous system, and turn stress into fuel so you build radical confidence that lasts. Listen to this classic with host Dave Asprey as he talks with entrepreneur, author, and Women of Impact founder Lisa Bilyeu. Lisa went from a stay-at-home “supporting role” to co-founding Quest Nutrition, scaling it into a billion-dollar company, and running a global media empire. She brings years of lived experience and applied mindset training, making her one of the most authentic voices on confidence, resilience, and leadership in the biohacking world. You’ll learn how to: • Hack confidence with the same strategies you use for sleep optimization, fasting, and cold therapy • Spot biological triggers behind fear, self-doubt, and procrastination • Use repetition and mindset tools to upgrade brain optimization and neuroplasticity • Turn stress hormones into growth signals for longevity and functional medicine practices • Reframe trauma and setbacks as power for resilience and high performance • Support courage and focus with nootropics, ketosis, supplements, and Danger Coffee This episode shows you how to treat confidence as a trainable skill, not a personality trait. If you want smarter not harder strategies to master your biology, expand your impact, and live with unshakable resilience, you’ll find them here. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes release every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Lisa Bilyeu, Radical Confidence, Quest Nutrition, Women of Impact, confidence training, resilience biohacking, mindset reprogramming, courage hacking, fear rewiring, entrepreneurial mindset, human performance, brain optimization, neuroplasticity tools, mitochondria and confidence, trauma resilience, emotional regulation, nootropics for confidence, stress as fuel, leadership confidence, Human Upgrade podcast Thank you to our sponsors! EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. Resources: • Lisa’s Website: https://lisabilyeu.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 0:38 – Intro 2:38 – From Housewife to Entrepreneur 17:52 – Building Impact Theory 27:56 – Radical Confidence 39:14 – The No BS Game 44:45 – Finding Purpose 55:34 – Inner Critic & Competence 1:01:10 – Becoming Your Own Hero 1:08:32 – Boundaries & Relationships 1:09:52 – Conclusion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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O The Human Upgrade: Biohacking for Longevity & Performance

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
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