The Diary Of A CEO with Steven Bartlett

What if the decline of your cognitive function isn't a genetic inevitability, but a metabolic choice you’re making every single day? Board-certified neurologist Dr. David Perlmutter discusses cognitive decay and outlines the definitive protocol for lifelong brain health and dementia prevention.

Dr. David Perlmutter is a pioneering researcher who radically challenged the medical establishment by linking metabolic dysfunction to severe neurodegenerative diseases. He is the author of several groundbreaking texts, including his most recent release, Brain Defenders. This project aims to empower individuals to regain agency over their longevity by harnessing the brain's immune system to reverse and prevent cognitive decline.

In this episode, he explains:
■ The Evil Twin Phenomenon: How high blood sugar and inflammation hijack your brain's protective microglial immune cells and shift them into a destructive state that actively devours healthy synapses.
■ The Power of Exercise: Why building muscle helps secrete protective chemicals to actively regenerate neurons and block cognitive decay.
■ The Oxytocin Shield: How deep social connections and community integration fundamentally alter your brain's inflammatory response and keep your neural immune system in a supportive state.
■ The Glymphatic Street Cleaners: Why missing out on stage four deep sleep immediately cripples your brain's ability to sweep out toxic amyloid-beta plaques overnight.
■ The 40Hz Reset: How specific frequencies of flashing light and sound can revert rogue brain cells back into protective guardians and restore your baseline neural rhythms.

https://stevenbartlett.com/wp-content/uploads/2026/11/Independent-Research-Perlmutter-DOAC-PhiloScript.pdf

Chapters

00:00:00 Intro
00:02:16 The Mission to Prevent Alzheimer's
00:07:36 When Does Dementia Actually Start?
00:11:57 The Top 5 Lifestyle Causes of Alzheimer's
00:13:53 Does the APOE4 Gene Mean You'll Get Alzheimer's?
00:16:27 How Exercise Can Cut Your Alzheimer's Risk
00:21:40 How Loneliness Raises Your Risk of Dementia
00:23:52 The Brain's Evil Twin Immune Cells Behind Alzheimer's
00:31:12 Is Alzheimer's the Brain Pruning Itself Like a Child's?
00:35:04 How Poor Sleep Damages Your Brain
00:38:22 How Inflammation Hijacks Your Decision-Making
00:41:34 How Much Sugar Is in Your Orange Juice?
00:44:54 What a Continuous Glucose Monitor Reveals About Your Diet
00:48:13 Gluten, Glyphosate and Your Brain
00:53:41 Ads
00:55:58 The Polyphenol-Rich Foods That Protect Your Brain
01:01:24 The Link Between Type 2 Diabetes, Alzheimer's and Parkinson's
01:03:08 Why Visceral Fat Is So Dangerous for Your Brain
01:05:13 Is Any Amount of Alcohol Safe for Your Brain?
01:08:15 Why Women Have Twice the Risk of Alzheimer's
01:10:25 Can 40Hz Light and Sound Help Treat Alzheimer's?
01:15:20 The Sugar Rationing Study That Cut Alzheimer's Risk by 40%
01:16:43 How Your Gut Microbiome Affects Dementia Risk
01:20:42 Why Head Injuries Cause Lasting Brain Damage
01:21:46 Ads
01:23:48 Why Head Trauma Is Worse for Type 2 Diabetics
01:25:07 Should Healthy People Take Metformin?
01:29:11 The Letter Dr. Perlmutter Wrote at 15
01:30:35 How Becoming a Grandfather Changed Dr. Perlmutter
01:33:37 What Can People With Alzheimer's Do Right Now?
01:36:38 Can a Ketogenic Diet Help Treat Dementia?
01:39:32 The Supplements Dr. Perlmutter Takes for Brain Performance
01:41:39 What Is It Like to Have Alzheimer's?
01:47:38 A Letter From His Son Austin
01:52:13 Why Reconnecting Is the Key to a Healthy Brain

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Dr. Perlmutter has a free resource for DOAC listeners, 10 questions to reveal how well your daily habits are protecting your brain’s future: 
The Brain Defenders Assessment - https://link.thediaryofaceo.com/ADzqL18

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Are you waiting for the perfect circumstances to pursue greatness, or using your past as an excuse to avoid hard work? Legendary comedian Katt Williams reveals the story of his childhood and the mindset that turned a 13-year-old runaway into an entertainment icon.

Katt Williams is an Emmy Award-winning stand-up comedian, actor, and writer, widely regarded as one of the most prolific and distinctive voices in modern comedy. Beyond his massive success on stage and screen, he is the author of a deeply revealing memoir detailing his extraordinary ascent from homelessness.

In this episode, he explains:
■ The Medicine of Humor: How discovering comedy provided an immediate escape from severe childhood abuse and instilled an unbreakable sense of internal control.
■ The Hero’s Delusion: Why reading classic literature convinced him that extreme hardship was merely a prerequisite for greatness, bulletproofing his mind against a victim mentality.
■ The Math of Rejection: Why treating rejection as a predictable numbers game completely erases the emotional pain of failure in both business and comedy.
■ The Illusion of "Overnight" Success: Why treating comedy like a grueling 9 to 5 job for 15 unrecognized years set the foundation to dominate both Black and white audiences.
■ The Ultimate Self-Bet: How funding his own early comedy specials removed all career risk and proved that relying on industry gatekeepers is the only true gamble.

Chapters

00:00:00 Intro
00:02:16 From Survival to Success
00:04:05 How a Very Different Childhood Shaped Everything
00:07:27 What It Took to Survive Childhood Abuse
00:13:17 When Did You Realise It Was Abuse?
00:17:21 Did Your Brothers Suffer the Same Treatment?
00:18:39 How Childhood Trauma Shapes Your Relationships
00:23:37 The Surprising Role of Religion in a Difficult Childhood
00:27:41 How Comedy Became a Way to Heal
00:30:53 Why I Had to Leave Home to Save My Brothers
00:36:53 What It Was Like Sleeping in a Park at 13
00:41:02 The Day My Family Finally Found Me
00:45:47 Ads
00:47:56 What Really Happened at Your First Stand-Up Show?
00:53:19 How I Ended Up Becoming a Pimp
00:56:40 What Made Me Return to Comedy?
00:58:26 What It Really Takes to Become Great
01:03:32 The Big Break That Changed Everything
01:13:44 The Life-Changing Lesson I Learned From Prince
01:17:07 The One Thing Every Artist and Creative Needs
01:19:04 How to Break Free From a Victim Mentality
01:23:52 Ads
01:24:11 Why I Never Turned My Back on Religion
01:27:21 Why Taking Risks Can Change Your Life
01:30:04 Where Does True Confidence Come From?
01:33:28 How to Take Back Control of Your Life
01:38:17 Why Believing in Yourself Changes Everything
01:42:36 Do You Still Have a Relationship With Your Parents?
01:44:48 Why Am I Acting Differently in This Interview?
01:46:42 The Advice Every Young Person Needs to Hear

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Are you trying to innovate before you truly understand the problem?
Daniel Ek is the co-founder of Spotify, the world's most popular audio streaming service, and the co-founder of preventative health company Neko Health.
In this moment, Daniel shares the approach that lets innovators crack problems most people write off as impossible, and why a healthy dose of delusion only works when it's paired with something far less glamorous. He takes you behind the scenes of how Spotify prepared for Apple Music's launch, explains how to tell when to keep going and when to walk away, and reveals why every team building something new needs a skeptic in the room.
Listen to the full episode here!
Spotify: https://g2ul0.app.link/G2QZbVroP7b
Apple: https://g2ul0.app.link/6bjbfAuoP7b
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Are we secretly sleepwalking into the most dangerous 8 weeks of our lifetimes? Professor Robert Pape reveals why the coming months could trigger unprecedented political violence and war escalation, and what it means for the future of global stability.

Robert Pape is a renowned political scientist who has spent the last 30 years studying global political violence and advising every US White House since 9/11. He is the author of several definitive books on military strategy and political instability, including his most recent work, Our Own Worst Enemies. His extensive research seeks to understand the root causes of violent populism and provide actionable frameworks to prevent geopolitical escalation traps.

This episode was recorded on October 29, 2026.

In this episode, he explains:
■ The Escalation Trap: Why international conflict is less like a strategic game of chess and more like a desperate gambler playing roulette to chase their mounting losses.
■ The "Instant Thunder" Threat: How a seemingly brief three-day aerial bombing plan could rapidly spiral into a prolonged war that paralyzes global infrastructure.
■ The Wildfire of Violent Populism: Why tens of millions of politically divided citizens currently act as combustible material waiting for a single structural spark to ignite widespread violence.
■ Invoking the Insurrection Act: The terrifying sequence of events that could legally place military troops on domestic streets to suppress protests during a transfer of power.
■ The Three Core Firebreaks: The specific demands ordinary citizens and global politicians must make to de-escalate tensions and prevent regional proxy battles from turning into World War Three.

Chapters

00:00:00 Intro
00:02:14 Why Political Violence Is on the Rise
00:02:14 How Did the Current Geopolitical Crisis Begin?
00:08:47 What Happens If Democrats Win the Midterms?
00:12:45 What Could Happen Week by Week?
00:14:58 How Will the Iran War End?
00:24:01 How the Midterm Elections Could Shake Up Crypto
00:27:34 What Is the Three-Day Plan and Why Does It Matter?
00:35:09 What Is an Inspired Attack and How Dangerous Is It?
00:41:09 Ads
00:46:10 What Does Putin Really Want From Ukraine?
00:49:30 What Happens to Ukraine After the US Midterms?
00:50:13 What Is Number 7 and Why Does It Matter?
00:52:22 How Could Both Wars End?
00:52:57 What Is Violent Populism and Why Is It Rising?
00:59:09 Why Is the UK Urging People to Stock Up on Cash, Water, and Batteries?
01:02:56 Ads
01:04:01 Did US Intelligence Tell Reporters to Ignore a Cyberattack?
01:08:21 Has the US Military Ever Been Deployed on American Streets?
01:11:39 Could US Ground Troops Be Sent Into Iran?
01:11:54 What Is the Insurrection Act and When Could It Be Used?
01:15:42 Are We Already Fighting Proxy Wars?
01:16:42 How Likely Is World War 3?
01:17:20 What Can We Do to Prevent World War 3?
01:20:18 What Should the Public Be Doing to Prepare?
01:25:08 Has the White House Made Direct Contact?

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Is political corruption and extreme inequality pushing the working class to the breaking point? Representative James Talarico reveals the hidden systemic forces dismantling the American middle class and shares his radical blueprint to fix a rigged political system.

James Talarico is an 8th-generation Texan, former public school teacher, and current Democratic State Representative. As the potential first Democratic Senator elected in Texas since 1988, he campaigns on a progressive platform rooted in comprehensive political reform and unrigging the economy.

This episode was recorded on September 8, 2026.

In this episode, he explains:
■ The Rigged System: Why the last 50 years of “trickle-down economics” is not an economic theory, but a deliberate theft designed to transfer wealth from the middle class to the ultra-rich.
■ Crony Capitalism: How monopolies in healthcare and lax campaign finance laws allow corporations to essentially purchase politicians, eliminating true competition and driving up prices for average citizens.
■ The AI Threat: Why leaving the development of artificial intelligence entirely to profit-driven billionaires threatens to create mass unemployment without any shared public benefits or worker protections.
■ False Immigration Choices: How politicians use extreme border rhetoric to divide voters, when the real solution requires simultaneous border security and clear, legal pathways to citizenship for undocumented residents.
■ Systemic Overhaul: Why simply electing new politicians changes nothing unless we first dismantle the corrupt incentive structures of gerrymandering, the two-party system, and unregulated corporate lobbying.

Chapters

00:00:00 Intro
00:02:24 Growing Up With a Single Mom Who Escaped Abuse
00:07:45 Why He Won't Run for President
00:14:08 Who Should the Democrats Run in 2028?
00:15:51 The Rise of Democratic Socialism and the Powell Memo
00:20:42 How to Rebuild the American Middle Class
00:25:07 Is the Texas Governor Corrupt?
00:27:54 Is It a Spiritual Sickness to Be a Trillionaire?
00:31:50 How Do You Tax Wealth That Isn't Cash?
00:36:01 Will Billionaires Just Leave the State?
00:38:30 Breaking Up Healthcare Monopolies
00:40:33 Ads
00:42:37 The 3 Things He'd Prioritize to Regulate AI
00:47:09 Should Billionaires Write the Rules for AI?
00:49:39 Will Self-Driving Cars Wipe Out Driving Jobs?
00:52:02 Is AI Headed Toward 30% Unemployment?
00:56:03 Did Woke Politics Hurt the Democrats?
00:57:40 Why Did Democrats Lose to Trump?
01:01:03 What Does He Really Think of Trump?
01:02:16 How to Fix Immigration Without Extremism
01:05:29 Ads
01:06:37 How Does America Get Out of the Iran War?
01:13:37 His Advice to Trump and Hopes for the Midterms
01:17:07 The Good Samaritan and the Faith That Shapes Him
01:20:36 Does He Love His Rival Ken Paxton?
01:23:13 Why He Went to Seminary at 31
01:27:33 Where Does His Faith in God Come From?
01:31:09 How Is He Different From Other Politicians?
01:34:33 His Biggest Challenge: Winning Texas

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