Skyline Drive: How to Live Forever

On a whirlwind trip to the Bay Area, Mangesh reconnects with a childhood friend who’s experimenting with new ways to optimize his health. Then, he heads to the heart of San Francisco to meet the investors, startup founders, tinkerers, and biopunks who are taking longevity science into their own hands. Plus: Skyline Drive’s first-ever musical number, about the bizarre Honduran charter city of Próspera.
Read more about Próspera from Wired and Bloomberg
Visit the Frontier Tower website
Check out Elliot Roth’s work
Learn more about Illumicell
Learn more about Muse Bio
Listen to more of David Nagler’s music
Check out Allie Oops on Tiktok
Special thanks to Azadi Records and Bliss Samsa for their beautiful tracks, and Botany for the score.
Episode collage art by Vahini Shori.
See omnystudio.com/listener for privacy information.

According to “mortality curmudgeon” Dr. Stephen Cave, humans have been inventing stories about immortality since the beginning of time. On a quest to unravel some of these myths, Mangesh finds himself wrestling with a literal fountain of youth in Chicago, playing left-handed tennis with an ambidexterity expert in San Diego, and discovering the Greek way of life with an old friend from last season. Plus: Meet Mr. Wonderful.

Watch Stephen Cave’s TED Talk and get his book, Immortality: The Quest to Live Forever and How It Drives Civilization
Check out Jim Houliston’s website, AmbiLife, and learn more about Ambidex Fitness
Check out George Aivaliotis’s comedy on Instagram

Special thanks to Azadi Records and Bliss Samsa for their beautiful tracks, and Botany for the score.
Episode collage art by Vahini Shori.
See omnystudio.com/listener for privacy information.

Mangesh hops a train to Boston, where he tries on a special suit that turns him into an 80-year-old, discovers the connection between elderly worms and high-end longevity supplements, and meets a scientist who’s growing brains in petri dishes (when she’s not throwing dance parties for mice). Plus: What really happened to Ted Williams’ frozen head?
Learn more about AGNES and Joe Coughlin’s work at the MIT AgeLab
Learn more about William Mair’s work with the Harvard Healthy Aging Initiative
Read Lenny Guarante’s research on SIR2 and the mechanisms of aging
Watch Li-Huei Tsai’s TED Talk about treating Alzheimer’s with light and sound, and learn more about the MIT Aging Brain Initiative
Special thanks to Azadi Records and Bliss Samsa for their beautiful tracks, and Botany for the score.
Episode collage art by Vahini Shori.
CORRECTION FOR THIS WEEK: Lenny was contacted by Sequoia, and a then-Sequoia partner is the co-founder and CEO of Elysium, but Sequoia is not an Elysium investor. The company is backed by other venture capital firms.
See omnystudio.com/listener for privacy information.

When an astrologer tells Mangesh that he’ll (probably) die early, he takes it in stride. But his family and friends (not to mention all the Don’t Die longevity influencers on his FYP) feel differently… and besides, if science can keep his brain sharp and his tennis game strong for longer, why not take advantage? So he visits Dr. Nir Barzelai, the world’s leading aging researcher, and Dr. Ron Primas, an elite longevity doctor, to figure out what he should do. Plus: A chat with Ken Reid from TV Guidance Counselor about age in pop culture, from the Golden Girls to “I’ve fallen and I can’t get up.”
Disclosure: The experts we spoke with want to be clear that although they have some minor quibbles with Bryan Johnson, they’re grateful for the fact that he’s started the conversation on longevity. Any insinuation that he’s got weird vibes is ours.
Listen to Ken Reid’s podcast, TV Guidance Counselor
Learn more about Nir Barzelai’s Longevity Genes Project and his book, Age Later
Learn more about Ron Primas’s longevity and concierge medicine practice
Read Cynthia Kenyon’s groundbreaking 1993 study of worm longevity
Check out the Ray Kurzweil Library
Special thanks to Azadi Records and Bliss Samsa for their beautiful tracks, and Botany for the score.
Episode collage art by Vahini Shori.
See omnystudio.com/listener for privacy information.

Mangesh Hattikudur (Part-Time Genius, Mental_Floss) dives into the booming business of living forever—meeting the scientists, biopunks, and entrepreneurs trying to turn immortality into reality, and framing death as a choice. But the more he learns about an immortal future, the more he finds himself drawn to the people he loves…and wondering if an endless life can be a meaningful one.
Skyline Drive: How to Live Forever is the follow up to the beloved Skyline Drive (season 1), named a “Series Essential” — an Apple Podcasts honor for top-tier narrative podcasts — and highlighted on several Best of Year lists including NYMag, Guardian, and others.
See omnystudio.com/listener for privacy information.