Longevity by Design

• Karl Pfleger Explains the Aging Biotech Explosion

  On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accumulated damage.Karl highlights the most promising areas in his investment portfolio, including senolytics for clearing senescent cells and epigenetic reprogramming technologies. He explains why current aging clocks aren't ready for clinical use and discusses the limitations of popular interventions like GLP-1 drugs and fasting protocols. The conversation reveals that 14 Phase 3 clinical trials are currently testing core aging therapeutics.The discussion covers recent FDA approvals for ATTR treatments and stem cell therapies, signaling the field's maturation. Karl emphasizes that meaningful life extension requires a "divide and conquer" strategy, targeting multiple aging mechanisms simultaneously rather than relying on single interventions. Despite exciting therapeutic developments, he maintains that optimizing diet, exercise, and sleep remains the most impactful strategy for extending healthspan today.Guest-at-a-Glance💡 Name: Dr. Karl Pfleger💡 What they do: Angel investor, philanthropist, and advocate in aging and longevity biotechnology💡 Institution(s): Creator and maintainer of AgingBiotech.info (comprehensive public database of 400+ aging companies)💡 Noteworthy: Exclusively invests in aging/longevity sector with 15+ portfolio companies targeting damage repair approaches💡 Where to find them: LinkedIn | AgingBiotech.info | X (Twitter)Episode highlights:00:00:00 Introduction to GLP-1 Drugs and Their Impact00:00:56 Meet Dr. Karl Pfleger: A Pioneer in Aging and Longevity00:02:50 Karl Pfleger's Journey from Tech to Aging Biology00:05:18 The Current State of Longevity Biotech00:09:47 Exciting Developments in Rejuvenation Biotechnology00:24:17 Aging Biotech Info: A Comprehensive Resource00:31:59 Future Plans for Aging Biotech Info00:36:51 The Obesity Revolution: GLP-1 Receptor Agonists00:40:29 Global Obesity Rates and GLP-1 Drugs00:40:43 Potential Benefits and Limitations of GLP-1 Drugs00:42:13 Muscle Atrophy and Side Effects of GLP-1 Drugs00:44:12 Emerging Muscle Aging Treatments00:46:10 Biotech Companies and Obesity Programs00:46:53 Public vs. Private Biotech Companies00:49:12 Fasting and Calorie Restriction00:55:20 Blood Transfusions and Parabiosis00:58:09 Metformin and N-of-1 Experiments00:59:13 Comprehensive Aging Interventions01:03:54 Diagnostics and Aging Clocks01:13:49 Future of Aging Interventions01:16:07 Top Tips for Health and LongevityWe Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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• How to Extend Your Healthspan with Dr. Eric Topol

  Gil and Eric discuss Eric’s book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide personalized recommendations for preventing age-related diseases.The conversation also explores the importance of exercise, sleep, and social connection for healthy aging, as well as the risks associated with high-dose statins. Eric emphasizes the need for a shift towards preventative care, using data and AI to identify and address individual risks. He stresses the power of lifestyle changes, rather than supplements, in improving long-term health outcomes.  Guest-at-a-Glance 💡 Name: Dr. Eric Topol 💡What they do: Founder and Director 💡Company: Scripps Research Translational Institute💡Noteworthy: Genomics pioneer, digital medicine innovator, and preventative care advocate    Episode highlights:[00:00] The Impact of Social Isolation on Health[01:19] Meet Dr. Eric Topol: A Pioneer in Medicine[03:16] Dr. Topol's Personal Journey into Medicine[05:31] The Early Days of Genetic Therapy[07:54] Insights from Dr. Topol's Book: Super Agile[13:02] The Role of Genetics in Longevity[14:22] The Five Dimensions of Healthspan[20:08] The Power of Exercise and Diet[23:58] The Truth About Supplements[32:38] The Importance of Sleep[36:07] The Value of Social Relationships[38:02] The Benefits of Nature and Social Interaction[39:17] Exploring Longevity Drugs: Metformin and Rapamycin[40:10] Risks and Benefits of Longevity Treatments[41:56] The Potential of GLP-1 Drugs[46:41] Statins and Their Impact on Health[51:11] Emerging Cancer Detection Technologies[56:15] The Role of AI and Polygenic Scores in Healthcare[57:36] Preventing Alzheimer's Disease[01:01:14] The Future of Longevity and HealthspanWe Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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• The Science of Muscle, Protein, and Longevity: Insights from Dr. Layne Norton

  In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stresses the power of personalized approaches to nutrition and fitness, advocating for a critical approach to information consumption.Layne dives into the complexities of protein intake, challenging common misconceptions. He advocates for a protein intake above the recommended daily allowance, stressing the role of muscle mass in overall health and longevity. Layne explains the importance of resistance training, even for older adults, to maintain muscle mass and reduce fall risk. He advocates for finding enjoyment in exercise, stressing that passion fuels consistency.Beyond physical health, Layne underscores the impact of mental health on longevity. He discusses the detrimental effects of stress, provides practical stress management tips, and encourages healthy boundaries. Layne’s holistic approach highlights lifestyle factors, nutrition, training, and stress management , as key drivers of a longer, healthier lifespan.Guest-at-a-Glance 💡 Name: Dr. Layne Norton 💡What they do:  Owner of BioLayne💡Company: BioLayne and the Carbon app💡Noteworthy: Nutrition scientist, fitness expert, and evidence-based educator bridging the gap between science and application.Episode highlights:[00:00:52] Introduction to Longevity By Design[00:01:03] Meet Dr. Layne Norton[00:02:00] Layne's Academic Journey[00:03:48] Choosing the Right Advisor[00:06:56] The Importance of Critical Analysis in Research[00:10:00] Transitioning from Academia to Public Communication[00:11:29] The Role of Social Media in Science Communication[00:13:33] Launching a Podcast and Future Plans[00:17:09] Understanding Risk and Misconceptions in Health[00:22:59] The Importance of Protein in Aging[00:41:50] Protein Consumption for Non-Daily Lifters[00:43:07] Debunking the Protein Timing Myth[00:45:31] Protein Distribution and Muscle Growth[00:50:09] Resistance Training for Older Adults[00:53:45] The Importance of Recovery and Sleep[00:56:15] Managing Psychological Stress[01:01:31] Wearable Data and Subjective Feelings[01:04:42] The Impact of GLP-1 Agonists on Weight Loss[01:09:47] Supplements for Health and Longevity[01:13:32] AI in Health and Wellness[01:14:46] Advice for Different Life Stages[01:17:45] Top Tips for Health and LongevityWe Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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• Beyond Sick Care: Evelyne Bischof on the Rise of Longevity Medicine

  On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society.  Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizing health span, not just lifespan, and how healthy longevity medicine benefits not only individuals, but population health and the world economy as well.Gil and Evelyne explore the difference between longevity medicine and traditional healthcare. Evelyne explains that longevity medicine uses a broader range of diagnostics, including advanced biomarkers, imaging, and cognitive tests. This approach aims to build a personalized health trajectory for each patient. They also discuss the role of AI in healthcare, with Evelyne expressing hope for faster, AI-driven diagnostics and drug discovery in the future.Finally, they touch upon the Healthy Longevity Medicine Society, its mission to establish longevity medicine as a recognized medical discipline, and the exciting developments in the field, such as the SHARP study at the Sheba Longevity Center. Evelyne emphasizes the importance of being data-driven and encourages listeners to collect and track their own health data. She believes this empowers individuals to make informed decisions about their health and longevity.Guest-at-a-Glance💡 Name: Dr. Evelyne Bischof 💡What they do: President💡Company: Healthy Longevity Medicine Society (HLMS)💡Noteworthy: Physician-scientist specializing in longevity and precision medicine.💡 Where to find her:LinkedInEpisode highlights:[00:01:24] Meet Dr. Evelyne Bischof[00:05:12] The Concept of Longevity Medicine[00:08:42] Health Span vs. Lifespan[00:11:39] The Role of Diagnostics in Longevity Medicine[00:22:54] Global Landscape of Longevity Medicine[00:29:50] Collaborations and Growth Initiatives[00:30:30] Monthly Case Studies and Activities[00:31:27] Membership and Target Audience[00:34:42] Organizational Structure and Leadership[00:39:52] Shiba Longevity Center Overview[00:45:22] Future of Longevity Medicine[00:50:27] Top Healthspan Tips and Final ThoughtsWe Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast 

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• Precision Habits: How Wearables and AI Are Powering Personalized Longevity

  In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity.The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a personalized weekly score. Rather than overwhelming users with multiple recommendations, the report focuses on one key habit to change, applying behavioral science principles for sustainable improvement.Deehan and Fabian detail how the system evaluates six weeks of data to identify trends and provide targeted recommendations, helping users bridge the gap between blood tests with actionable weekly guidance based on scientific research linking these habits to longevity outcomes.Guest-at-a-Glance 💡 Name: Dr. Renee Deehan 💡 What she does: Senior Vice President of Science and Artificial Intelligence 💡 Company: InsideTracker 💡 Noteworthy: Expert in precision health with a PhD from UC Berkeley 💡 Where to find her:LinkedInGuest-at-a-Glance 💡 Name: Paul Fabian 💡 What he does: Researcher 💡 Company: InsideTracker 💡 Noteworthy: Specializes in genetics,  exercise biomarkers, and data-driven health recommendations 💡 Where to find him:LinkedIn Episode highlights:Introduction to Healthspan and Lifespan 00:00:00Meet the Experts: Dr. Renee Dhan and Paul Fabian 00:01:07Paul Fabian's Journey to Science 00:03:24Introducing the Health Span Habits Core Tool 00:04:31Inspiration Behind the Health Span Habits Core 00:05:07How the Health Span Habits Core Works 00:06:40Personalized Health Recommendations 00:08:02How does  Insight Tracker turn intent into action 00:10:16How the Health Span Habit Score is Calculated 00:13:25The Importance of Bedtime Consistency 00:22:00Behavioral Science in Health Tracking 00:25:35User Feedback and Future Directions 00:31:38Final Thoughts and Tips for Longevity 00:42:20 We Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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