The Signal with Jonathan Jarecki

In this episode, my guest is Dr. Roger Seheult, MD, is a physician quadruple board-certified in internal medicine, pulmonary disease, critical care medicine, and sleep medicine, an Associate Clinical Professor at the University of California, Riverside School of Medicine, an Assistant Clinical Professor at Loma Linda University, and the co-founder of MedCram. 

Today, he explains why vitamin D levels strongly predicted COVID-19 outcomes while vitamin D supplementation largely failed to reproduce the benefit, and makes the case that vitamin D is a marker for sunlight exposure rather than the primary mechanism behind it. He describes the near-infrared portion of sunlight which penetrates through the human body, and the hypothesis that it stimulates melatonin produced inside mitochondria, where it acts as a local antioxidant. We discuss randomized trials of infrared light in hospitalized and ICU patients, why greenery reflects infrared while concrete absorbs it, the Green Heart Louisville tree-planting trial, evidence that bright light at night predicts higher mortality, the NEWSTART framework, the Adventist Health Study, and published research on faith, forgiveness, and health. 

FULL SHOW NOTES: https://docs.google.com/document/d/1uJxnUa3ifCtHbE11v3iQwgTD1-nQD90-PttuS5NN640/edit?usp=sharing

Sponsor: Solius 
https://shop.solius.com/JONATHANJ 
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About this guest:
Med Cram: https://www.medcram.com/
YouTube: https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ 
X: https://x.com/rogerseheult?lang=en 
Academic Profile: https://llu.edu/academics/faculty/seheult-roger/education 

Subscribe to the Newsletter: https://jonathanjarecki.substack.com/

Timestamps 
00:00 Intro
02:29 Dr. Roger Seheult
02:59 Dr. Seheult's Love for Science and Medicine
10:41 Pillars of Health, "NEWSTART"
13:11 Sunlight, COVID, Vitamin-D Paradox, Dr. Seheult's Clinical Experience
17:08 Extra-pineal Melatonin, Antioxidant, COVID, ACE2 Receptor, Red Light
18:50 Bringing Patients Outside in Sunlight
20:05 Sponsor: Solius
25:14 Melatonin, Infrared Light
27:13 Heliotherapy, Sunlight in Modern Hospitals,  Dr. Rollier, John Harvey Kellogg
33:18 Mitochondria, Long-Wavelength Light, Metabolism, Light Penetration Depth
36:03 Greenery, Infrared Light Bath, Longevity, New Data, MiEye
42:29 Audience Questions
42:41 Sunlight on Psychological Health
43:47 Artificial Light at Night, Longevity, Mortality
47:32 Cloud Coverage, Light Exposure
49:40 New Paper Being Published with Dr. Seheult, Dr. Jeffery, Dr. Fosbury, & Zimmerman 
50:37 Nutrition
53:28 Adventist Health Study, Plant-Based Nutrition, Mechanisms of Action, High Protein
01:01:15 Trust: The Science-Backed Health Benefits of Faith
01:19:28 Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Social Media, Substack Newsletter

In this episode, my guest is Dr. Sean Cain, PhD, a Harvard Medical School-trained expert in the impact of light on the human circadian system, a Matthew Flinders Professor at Flinders University, and Co-Founder and CEO of Circadian Health Innovations. 

Today, he discusses how people differ more than fiftyfold in how sensitive their circadian systems are to evening light, that nearly half of modern homes are bright enough at night to suppress melatonin by fifty percent, and that most of us have no conscious awareness of any of it. We discuss the large observational studies he and his team have published linking bright days and dark nights to depression, type 2 diabetes, cardiovascular disease, and mortality, as well as his research on impaired light sensitivity in depression and why the amplitude of your circadian rhythm may matter more than its timing. We also discuss MiEye, the wearable light sensor his team developed, and practical changes to home and daytime lighting that anyone can make tonight.

CLICK HERE FOR THE FULL SHOWNOTES
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Timestamps 
00:00 Intro
03:54 Dr. Sean Cain
04:42 Dr. Cain's Love for Science and Research
10:25 Understanding Circadian Rhythms: Anatomy and Function
10:56 Setting the stage: Circadian Biology, Rhythms, SCN, ipRGCs
16:20 Light, Circadian Entrainment, Mechanisms
19:57 High Sensitivity and Interindividual Variability in the Response of the Circadian of the Human Circa
22:02 Individual Sensitivity to Light and Circadian Disruption
27:22 Home Lighting, Sunset, LEDs, Fluorescents, Incandescents
27:37 Home Lighting and Its Effects on Circadian Health
33:46 Tools: circadian friendly home lighting
39:24 Population health outcomes; UK BioBank
39:29 Psychiatric Disorders
47:52 SPONSOR: Brighter Lamp
49:34 The Link Between Light Exposure and Mental Health
01:04:18 Light Exposure and Longevity: Key Findings
01:09:45 The Importance of Daylight for Health
01:17:41 Understanding Circadian Rhythms and Light Exposure
01:17:52 The Impact of Light on Mood and Self-Perception
01:23:39 Innovations in Circadian Health: My Eye Device
01:34:15 Jet Lag Management and the Jet Lag App
01:39:09 Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Social Media, Substack Newsletter

My guest is my mom, Rosebud, a mother of four who spent fifty years building a life around preventative medicine.

In this episode she tells her whole story: growing up with no money in Ozone Park, Queens; losing her father at three, her brother at thirty-two, and her first husband at twenty-five; and how that grief turned into a set of convictions about how she wanted to raise her children. We talk about the plant-based, vegetable-heavy way we ate growing up, the natural births, the years she spent learning from John Galamaga, and the pushback she took for doing things differently.

Newsletter: https://jonathanjarecki.substack.com/

Full Show Notes: https://docs.google.com/document/d/11ISCy3tLwVzrfEq-lR3jvp6qdYoZCOqB3GheuYJqC4s/edit?usp=sharing

*Disclaimer: This episode is a personal and family history, offered for educational and general-interest purposes only. It is not medical advice and should not be used to diagnose or treat any condition. Neither the host nor the guest is a licensed medical professional. Nothing here is a recommendation for how you should care for yourself or your children — please consult a qualified physician about your own health decisions.

Timestamps:
00:00 Intro
03:08 Mom
04:53 Mom's childhood, family situation, & diet
09:28 Relationship with the doctor growing up, health habits
10:43 Mom's mom (grandma)
13:14 First daughter
14:38 Vaccines, mom worked as a medical assistant
15:41 How my mom thought about health growing up; diet, medications, vaccines, sunshine
18:49 First husband passed away, life changed, breastfeeding
21:32 Meeting my dad, second child, Grandma's first heart attack
23:12 Finding John Galamaga; Dad having seizures, dad's health transformation
29:54 Natural Childbirths
32:59 Grandma's heart attack, heart health, health transformation
36:03 Experience raising her children, no meltdowns, vaccine exemptions
36:55 Dad being a chriopractor
38:24 Dairy, juicing, diet, healthy snacks
41:18 Surprise baby (Jonathan), limited doctor visits, high risk child, childbirth
44:22 Pregnancy with Jonathan, lifestyle, diet, doctor visits
48:48 Master Lowe, qigong, pregnancy
52:59 Delivering Jonathan in the hospital
57:42 Refusing childhood medical interventions; Vaccines, PKU, Vitamin K, hospital stay time
01:01:31 Leaving the hospital, home environment
01:03:46 Infrared sauna protocol, walking, magnet therapy, hydrogen water, epsom salt bath,
01:05:34 Family dynamic while raising children
01:06:26 The divorce
01:09:37 No medications; Tylenol, Advil, cough syrup... oh my!
01:10:22 Symptoms when I got sick
01:12:03 Diet, Hippocrates
01:16:53 Menopause, bone density, bioidentical hormones
01:21:32 The sacrifice of raising children
01:22:48 Tofu on hormones; testosterone, estrogen...
01:29:16 Restrictive diets on menopause
01:30:10 Food when we were sick; diet, resting, immune system
01:31:38 Gerson Therapy, white potatoes, cancer, low protein
01:36:46 Feeling energized throughout the day
01:38:43 Specifics on the diet
01:39:55 Importance of self education; Book recommendations
01:49:42 Audience Questions:
01:50:02 How did your kids go to school without vaccines?
01:52:11 Essential oils
01:54:38 Did we have any allergies growing up?
01:56:30 Daycare; navigating different environments
01:59:34 What to do when you catch the flu?
02:00:15 Bentonite and Psyllium cleanse protocol
02:02:29 My mom's personal health
02:05:54 Jaundice remedy
02:06:41 Replacements for Tylenol
02:07:34 Did you get any pushback for raising your children vegan?

In this episode, my guest is Dr. Glen Jeffery, PhD, a professor of neuroscience at University College London's Institute of Ophthalmology and a leading expert on how light interacts with mitochondria to shape health and aging. 

Today, he discusses how red and near-infrared light penetrate deep into the body and improve mitochondrial function and overall health. We also discuss how detrimental modern indoor life has become and why expensive red light panels are likely unnecessary and possibly harmful.

By the end, you'll understand sunlight as a biological input your body evolved to depend on and the low-cost, practical steps you can take to get more of it.

FULL SHOW NOTES HERE: https://l1nk.dev/bjuu235

Sponsor: Shadowmap  
https://app.shadowmap.org/?ref=jonathan&discount=JONATHANJ 
Code: JONATHANJ   

Sponsor: Ra Optics
https://www.raoptics.com/JONATHANJ 
Code: JONATHANJ 

About this guest:

Academic Profile: https://profiles.ucl.ac.uk/7465 
Google Scholar: https://scholar.google.com/citations?user=UYlObKkAAAAJ&hl=en 
LinkedIn: https://www.linkedin.com/in/glen-jeffery-441a2b1b/ 

Timestamps:
00:16 Intro
02:46 Dr. Glen Jeffery
03:14 Love for Science, Undergraduate
04:24 Tiina Karu, Photobiomodulation Origins, Mechanisms 
06:14 Mechanisms, Cytochrome C Oxydase, Nanowater, Electron Flow
10:56 Cytochrome C Oxydase, Extra-Pineal Melatonin, Oxidative Stress
12:45 Gerald Pollack, Exclusion Zone (EZ) Water
13:45 Red/IR Light Passes Through the Human Body; Optics
18:09 Red Light On Fruit Flies; Lifespan, ATP Production
21:15 Human Epidemiology; Sunlight, Lifespan, All-Cause Mortality
22:35 Sponsor: Shadowmap
23:30 Features and Benefits of Shadow Map
25:02 Incandescents, lifespan, and more
25:02 Incandescent Light Produces the Oldest Flies; Broad Band IR on Lifespan
25:48 Incandescent Light Bulbs, Vision 
28:19 Evolutionarily Conserved Mitochondria
29:03 Long-Wavelength Light & Blood Glucose; Mitochondria
32:50 Unpublished CGM Data; Long-Wavelength Light & Blood Glucose
36:57 Are Red Light Panels Harmful?; Light Intensities, Precautions, Mitigations
43:56 Why Do We See Beneficial Effects From Long-Wavelength Therapy? 
46:43 Short-Wavelength Blue Light, Mitochondria, Mechanism
49:08 The Built Environment, Actionable Steps 
52:24 Sponsor: Ra Optics
54:24 Flicker
55:24 Retinal Health, Blue Light, Red/IR Light
59:09 Clinical Trial for Mitochondrial Disease; Ptosis, Red Light
01:02:31 Biophotons, Mitochondrial Communication, Red/NIR on Biophotons 
01:13:54 Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Social Media, Substack Newsletter

Dr. Max Gulhane (MD) is a practising family medicine physician and health-optimising physician with a passion for root-cause analysis of human chronic disease and longevity. We discuss the full solar spectrum and how ultraviolet, visible, blue, red and near-infrared light each affect human physiology, including the POMC pathway, nitric oxide and blood pressure, and the evidence on sunlight, skin cancer and the vitamin D paradox. We discuss how artificial light at night suppresses melatonin and disrupts the circadian control of DNA repair, cardiovascular health, and metabolism. For those interested in light and circadian health, Dr. Gulhane offers a grounded, mechanism-focused framework for aligning daily light exposure with human biology.

Full Show Notes here.

Thank you to our sponsor
Daylight Computer: daylightcomputer.com (code JONATHANJ for $25 off)

Dr. Max Gulhane
Website: https://www.drmaxgulhane.com/
Instagram: https://www.instagram.com/maxgulhanemd/
X: https://x.com/MaxGulhaneMD
YouTube: https://www.youtube.com/@maxgulhanemd/

Recommended lectures:
Sunlight & Cancer: Beyond Skin Deep — https://youtu.be/SJGvr6dGOgQ
Artificial Light & Diabetes: No Food Required — https://youtu.be/vgrFpPusSKU
What Your Cardiologist Doesn't Know About Sunlight & Heart Health — https://youtu.be/NaeqPHEM-d0

Jonathan Jarecki
Instagram: https://www.instagram.com/jonathanjarecki/
X: https://x.com/jonathanjarecki
Newsletter: https://jonathanjarecki.substack.com/?utm_campaign=profile_chips

00:00 Intro
03:25 Dr. Max Gulhane
04:02 Dr. Gulhane's Love for Science and Medicine
09:01 What is Light?
12:52 Sunlight Broken Down as a Nutrient
14:02 Ultraviolet Light: Sunlight Is More Than Vitamin D
15:56 POMC
21:38 UVA/UVB on Cardiometabolic Health
24:40 Big Picture of UV Light
28:41 Sunlight, Skin Cancer, Dermatology Messaging, The Vitamin D Paradox
35:10 Blue Light, Artificial Light at Night (ALAN), Mechanisms
38:50 Sponsor: Daylight Computer
40:34 ALAN, Epidemiology, Cancer, Heart Disease
45:04 DNA Repair Mechanisms, Circadian Control
47:27 Melanopsin (OPN4), Blue Light, UV Susceptibility
53:25 Red, Infrared, Photobiomodulation, Metabolism
01:00:08 Blue Light, Metabolism, and the Built Environment
01:05:19 Photobiology of Atherosclerosis
01:10:11 Blue Light on Cardiovascular Function
01:12:25 Three M's of Circadian Health
01:18:43 Sunlight, Testosterone, and Reproductive Behavior
01:24:14 Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Social Media, Substack Newsletter

#science #sunlight #circadianrhythm