Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)?
In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle?
Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase.
You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines. Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement.

In This Episode You'll Learn:
What PMDD is and how it differs from PMS
The relationship between histamine and women's hormones
How estrogen can increase histamine levels
The role of progesterone in histamine regulation
Mast cell activation and hormone-related symptoms
Why histamine may worsen anxiety, irritability, and mood swings
The science behind H1 and H2 blockers
Potential risks of long-term antihistamine use
Histamine's effects on neurotransmitters including serotonin and dopamine
The connection between PMDD, MCAS, and histamine intolerance
Why methylation may play a role in PMDD symptoms
Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction
Natural strategies for addressing histamine-related hormone symptoms
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve.
In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified.
You'll learn how three key factors often work together to impair cellular energy production:
Mycotoxins and their direct toxic effects on mitochondria
Sulfur depletion and reduced glutathione production
Oxalate accumulation and mitochondrial stress
Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation.
This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness.
Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery.
In this episode, you'll discover:
How mould toxins damage mitochondrial function
Why fatigue often persists despite rest and sleep
The critical role of sulfur in energy production and detoxification
How oxalates can contribute to mitochondrial dysfunction
Common signs of mould-related mitochondrial impairment
Why addressing mould exposure alone may not be enough for recovery
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction.
If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction.
Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed.
In this episode, you’ll learn:
Why mould illness and SIBO commonly occur together
How poor vagal tone affects digestion and bacterial overgrowth
The connection between mould, histamine intolerance, and mast cell activation
Why low stomach acid and sluggish bile flow can worsen gut symptoms
How chronic inflammation disrupts gut motility and digestive function
Why antibiotics and herbal antimicrobials may not fully resolve SIBO
The importance of mould testing in chronic gut health conditions
#SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation.
Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms.
In this episode, Joanne explains:
How poor bile flow contributes to histamine intolerance
Why mold toxicity and mycotoxins affect the liver and gallbladder
The vicious cycle between SIBO and bile dysfunction
How estrogen dominance impacts bile flow and histamine
Why oxalates can worsen inflammation and histamine symptoms
The role of methylation and phosphatidylcholine in healthy bile production
How vagus nerve dysfunction affects digestion and bile release
Common signs and symptoms of poor bile flow
This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms.
🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine.
#HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.
High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12.
Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements.
In this episode, you’ll learn:
 • What high homocysteine means and why it matters
 • The connection between homocysteine and methylation
 • Why methylated B vitamins can trigger symptoms
 • Histamine intolerance and supplement sensitivity
 • The role of MTHFR, COMT, and methylation pathways
 • Overmethylation vs undermethylation explained
 • Practical clinical insights for improving tolerance to methyl nutrients
Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing.
Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!