Skin Anarchy

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In this special episode of Skin Anarchy, Dr. Ekta Yadav welcomes back Madhavi Gavini, founder of Droplette—one of the earliest science-forward brands featured on the show. What once felt like a radically different approach to skincare technology now feels increasingly relevant as the industry shifts toward biologics, regenerative ingredients, and delivery science. The conversation revisits Droplette’s origins and explores why effective delivery may be the missing piece in modern skincare innovation.
Gavini’s journey into skincare began far outside the beauty industry. With a background in pharmaceutical development, she spent years designing therapies for pediatric diseases, where she encountered one of medicine’s most persistent challenges: delivery. Even when researchers identify the therapeutic molecule that could help treat a condition, getting that molecule into the correct layer of skin is often the hardest part. That realization became the foundation of Droplette’s technology, originally developed alongside MIT-affiliated researchers to enable large molecules to reach skin tissue without needles or barrier injury.
The Droplette device generates high-velocity, submicron droplets capable of moving ingredients past the stratum corneum—the skin’s protective outer barrier—allowing molecules far larger than traditional topical ingredients to access viable layers of skin. The implications extend beyond cosmetics, with ongoing collaborations exploring delivery for antibiotics, gene therapies, and other advanced biologics.
The episode also dives into the science behind exosomes—one of the most talked-about yet misunderstood areas in regenerative skincare. Gavini explains what exosomes are, why sourcing and stability matter, and why many topical exosome products degrade or fail to penetrate the skin barrier. Double Board-Certified Dermatologist, Dr. Dan Belkin, also shares his clinical perspective on how exosomes are currently used in dermatology and why reliable sourcing, cold-chain handling, and effective delivery systems are essential for maintaining biological activity.
Listen to the full episode to hear Madhavi Gavini explain how Droplette is bringing pharmaceutical-grade delivery science into the future of regenerative skincare.
Use discount code 'ANARCHY' to get the Exosome Starter Set on subscription for just $349
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1.Quek BL, Srinivas RL, Gavini MP. Droplette: a platform technology to directly deliver nucleic acid therapeutics and other molecules into cells and deep into tissue without transfection reagents. Methods Mol Biol. 2022;2398:211-230. doi:10.1007/978-1-0716-1811-0_14.

2.Mahmood A, et al. Droplette—a fluid dynamics-driven platform for transdermal and intracellular delivery of large molecules. FASEB J. 2018;31(S1):924.7.

3.Pulakat L, Chen HH, Gavini MP, Ling LA, Tang Y, Mehm A, et al. Transdermal delivery of high molecular weight antibiotics to deep tissue infections via Droplette Micromist Technology Device (DMTD). Pharmaceutics. 2022;14(6):1134
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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with beauty industry veteran and product innovator Lorne Lucree to explore an unexpected frontier: allergy care. After decades helping shape iconic brands across L’Oréal, Estée Lauder, and Unilever Prestige, Lucree turned his attention to a category that had remained largely unchanged. What he discovered was striking—while skincare had evolved into a science-driven, barrier-focused discipline, allergy care still relied on reactive treatments designed for symptom suppression rather than biological support. That’s why he created Wizard Wellness.
The conversation reframes the nasal cavity not simply as an airway, but as a living barrier system—one with its own microbiome, immune signaling, and protective function, much like the skin. When that barrier becomes disrupted, allergens and pollutants penetrate more easily, triggering inflammation that extends far beyond congestion, affecting sleep, mood, and overall resilience. Instead of approaching allergies as isolated flare-ups, Lucree saw an opportunity to apply principles from microbiome skincare: support the environment itself so the body can defend more effectively.
Lucree shares how advances in microbiome science opened the door to a new preventative model—one that focuses on restoring equilibrium rather than sterilizing or suppressing. He also reveals the complexity of formulating for mucosal tissue, where safety, compatibility, and biological precision become paramount.
At its core, this episode explores how consumer health categories evolve when science, design, and behavioral insight converge. Listen to the full episode to hear Lorne Lucree explain how barrier biology and microbiome innovation may redefine allergy care—and why the future of wellness begins with protecting the body’s most overlooked interfaces.
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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with double board-certified dermatologist Dr. Sabrina Fabi to examine how hormonal signaling actively shapes skin resilience, recovery, and structural integrity. This conversation moves beyond trend-driven skincare and into the biology that determines how skin functions at every stage of life.
Dr. Fabi emphasizes that skin constantly responds to hormonal shifts. Changes in progesterone, estrogen, testosterone, and neurohormones influence collagen production, barrier strength, inflammation, muscle tone, and healing capacity. Aging reflects signaling patterns — not just the passage of time. When hormones fluctuate, skin behavior changes.
A central focus of the discussion is oxytocin. While most people associate oxytocin with bonding and mood, Dr. Fabi explains that skin contains oxytocin receptors that participate in local repair and inflammatory signaling. That neuroendocrine connection reframes how we think about resilience. The brain and skin communicate continuously, and hormonal signaling drives that dialogue.
Dr. Fabi applies this signaling-first framework directly through XOMD. Instead of topically applying exogenous hormones, she built XOMD around activating intrinsic pathways that support recovery and tissue strength. The focus remains on optimizing communication within the skin rather than overwhelming it with isolated actives.
Throughout the episode, she challenges casual aesthetic culture and reinforces the importance of individualized, long-term planning. Hormones shape anatomy, metabolism, and tissue quality — treatment strategies must reflect that complexity.
Listen to the full episode to hear Dr. Sabrina Fabi break down hormonal biology, oxytocin science, and how XOMD advances a more intelligent approach to skin resilience.
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In this special installment of Skin Anarchy’s Lessons in Longevity series, Dr. Ekta Yadav sits down with beauty industry pioneer Melisse Shaban for a conversation that bridges decades of brand leadership with the cutting edge of cellular science. From her early days at Revlon’s counter at Macy’s Herald Square to leading Aveda and The Body Shop — and later founding science-driven ventures like Virtue Labs and Aramore — Shaban has witnessed beauty evolve from aspiration to physiology.
But this episode isn’t about nostalgia. It’s about where we’re headed.
Together, Dr. Yadav and Shaban unpack how the narrative around aging is shifting. Youth is no longer the sole benchmark of beauty. Instead, vitality, recovery, and cellular performance are redefining the industry. Skincare is moving beyond “hope in a jar” marketing toward biologically grounded innovation — often rooted in research that began in oncology, peptide science, and regenerative medicine labs.
A central theme of the conversation is NAD — a molecule essential for cellular energy and mitochondrial function. Rather than attempting to apply NAD topically in ways the skin cannot absorb, Shaban explains how Aramore focuses on supporting the body’s own NAD production through metabolically intelligent pathways. The message is clear: aging begins at the cellular level, and true longevity requires daily metabolic support — not reactive damage control.
This episode also tackles accountability in a crowded, hype-driven market. Clinical rigor, mechanistic plausibility, and transparent data are no longer optional — they are the future.
Listen to the full episode of Skin Anarchy to hear Melisse Shaban break down cellular energy, NAD science, and why the next era of beauty belongs to longevity-driven innovation grounded in real biology.
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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with longtime friend and beauty industry force Jaimee Holmes for an intimate conversation that marks a new chapter in her career—the launch of Fel. Known for shaping some of the most iconic products in prestige beauty, Holmes opens up about the personal experiences, creative pauses, and emotional clarity that ultimately led her to build something entirely her own.
The episode traces Jaimee’s journey from her early days at Sephora—where she learned the power of founder vision and retail storytelling—to pivotal roles at Benefit, Perricone MD, and Too Faced. She reflects on leading the launch of Better Than Sex Mascara, the conviction it took to push past skepticism, and how trusting instinct over trend can redefine an entire category. Later chapters at Kendo and Goop offered a different lens: overseeing countless brands and SKUs revealed just how crowded—and emotionally disconnected—the industry had become.
That realization, paired with personal loss and reflection, became the quiet catalyst for Fel. Rather than chasing what’s next, Holmes chose to look inward—building a brand rooted in nostalgia, emotion, and the universal language of a kiss. Fel’s debut, Kissylips, is designed to be felt as much as worn: playful, tactile, and intentionally uncomplicated, with packaging and textures that evoke memory rather than perfection.
At its core, Fel is about responsibility and care—especially for younger consumers. From globally clean, vegan formulations to a proprietary fel-good complex™ designed to support both the lip barrier and emotional wellbeing, every detail is deliberate. This isn’t makeup built for speed or spectacle—it’s built for connection.
Listen to the full episode of Skin Anarchy to hear Jaimee Holmes share how Fel came to life, why meaning matters more than momentum, and how beauty’s future may be rooted in feeling something again.
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