How to Turn Failure into Moonshots with Astro Teller of X, Alphabet's Moonshot Factory
What if the secret to solving impossible problems isn't avoiding failure, but learning to leverage it? Serial entrepreneur and inventor Astro Teller, Captain of Moonshots at X (Alphabet's Moonshot Factory), discovered this counterintuitive truth growing up in a family where intelligence was everything. The grandson of Edward Teller, father of the hydrogen bomb, and a Nobel Prize-winning economist, Astro learned that being smart wasn't enough. He had to develop his creativity into his philosophy of "being yourself on purpose." Today, Astro is responsible for steering X’s projects—like Waymo, Dandelion, and Verily—through the bumps and scrapes they meet along the road to reality. In this episode, Astro shares how childhood stories of the Manhattan Project's creative community inspired X's culture, why he transformed from trying to outsmart employees to becoming a "culture engineer," and why intellectual honesty is the real key to turning science fiction into reality.
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How to Swing Big with Alex Hawkinson of BrightAI
What if we could predict infrastructure failures before they happen instead of scrambling to fix them after disaster strikes? Serial entrepreneur Alex Hawkinson quips that the Romans would be laughing at us if they saw our current approach to managing the critical systems that power our world. Known as the father of IoT for creating SmartThings—a platform supporting over one billion connected devices before its acquisition by Samsung—Alex is now tackling his most ambitious challenge yet: awakening America's crumbling infrastructure through physical AI. With nearly 500,000 sensors already deployed across water, energy, and essential services, BrightAI is shifting entire industries from reactive maintenance to proactive intelligence. In this episode, Alex shares how BrightAI's observability layer creates an unbreakable competitive moat, how his "swing big" philosophy attracts world-class talent, and why transforming infrastructure management represents humanity's next great technological leap forward.
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How to Ask the Right Questions with Ben Lamm of Colossal Biosciences
What happens when humanity faces the sixth mass extinction event in Earth's history? Serial entrepreneur Ben Lamm believes we need a backup plan. With a track record of building and exiting companies across AI, gaming, and conversational intelligence, Ben took on his most audacious venture in 2021: co-founding Colossal Biosciences with Harvard geneticist Dr. George Church to bring extinct species back to life. The company has already successfully de-extincted the dire wolf and aims to return woolly mammoths to the Arctic by 2028. In this episode, Ben shares how his self-described "unemployable" streak became his entrepreneurial superpower, why asking naive questions helps him tackle impossible challenges across industries, and how Colossal's breakthrough technologies represent humanity's essential insurance policy for planetary survival.
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How to Innovate Without Compromise with Jon Perl of QA Wolf
With software powering every aspect of our lives, when does quality testing shift from a nicety to an absolute necessity? Despite the stakes, most companies fail to test everything—and even fewer automate their QA processes—leaving critical systems vulnerable to catastrophic bugs. Jon Perl is on a mission to change that. In 2019, he launched QA Wolf to help hundreds of companies automate 80% of their quality assurance processes, accelerating release cycles fivefold and saving customers over $100 million annually. By disrupting the outdated, manual QA status quo, QA Wolf empowers teams to ship faster and more confidently, delivering innovation without compromise. In this episode, Jon shares how a tech mistake sparked the idea for QA Wolf, how they settled on a pricing model that aligns incentives with their customers, and why he believes human-in-the-loop will remain essential until AI achieves flawless accuracy.
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How to Innovate at the Speed of Light with Nick Harris of Lightmatter
For 60 years, Moore's Law and Dennard scaling drove the exponential advancement of computers, making them faster, smaller, and more energy-efficient. But as Nick Harris explains, the era of transistor-based technology has reached its physical limits. The future of computing demands a new solution, and that solution is light. Nick founded Lightmatter in 2017 to fully transform AI data center infrastructure. By harnessing light to process and transmit data, Lightmatter is laying the foundation for the next generation of computing. The company invented the world's first 3D-stacked photonics engine and was most recently valued at $4.4 billion. In this episode, Nick shares why he chose to leave academia after receiving his PhD, how his go-to-market strategy hinged on building real friendships and understanding his customers' internal roadmaps, and why he believes that having an obsession is a gift.
Inspired with Alexa von Tobel dives headfirst into conversations with the most ambitious people on the planet. Host Alexa von Tobel, Founder and Managing Partner of Inspired Capital, gets under the hood of guests’ ambitions, from pivotal childhood moments to the critical advice that shaped their life paths. What does it take to be a true visionary, one who stares down monumental challenges with grit and resilience? Learn directly from those builders and problem-solvers whose determination is shaping a brighter, more inspired future.
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